Polynucleotide (PDRN) Therapy

DNA-repair molecules that rebuild skin from within

Polynucleotide (PN) or PDRN therapy uses long-chain DNA fragments — extracted from salmon sperm cells and purified to pharmaceutical grade — to stimulate the body's own DNA repair mechanisms. These bio-compatible molecules activate PDRN receptors in skin cells, triggering fibroblast proliferation, collagen and elastin synthesis, and deep tissue hydration. The result is measurably younger-looking skin with improved elasticity, tone and radiance.

Unlike hyaluronic acid skin boosters that add volume externally, polynucleotides work intracellularly — instructing your own skin cells to produce new structural proteins. This makes them ideal for patients who want biological skin improvement rather than filling or volumising.

Key Benefits of Polynucleotide (PDRN) Therapy in Abu Dhabi

Stimulates fibroblasts to produce new collagen and elastin
Improves skin hydration at a deeper level than topical moisturisers
Repairs UV-damaged, dehydrated and thinning skin
Reduces dark under-eye circles caused by thin, transparent skin
Excellent for delicate areas: under-eyes, neck, décolletage, inner arms
Highly biocompatible — salmon DNA PDRN has a 97% genetic similarity to human DNA

Is Polynucleotide (PDRN) Therapy Right For You?

Ideal Candidates

Patients with sun-damaged, dehydrated or photoaged skin
Those with thin, crepey skin under the eyes or on the neck
Anyone wanting biological collagen stimulation without volumising
Patients recovering from aggressive laser or chemical peel treatments
Those maintaining results from surgical or non-surgical rejuvenation

What to Expect During Your Polynucleotide (PDRN) Therapy at Enfield Royal

Skin Assessment

VISIA analysis or clinical assessment to identify areas of dehydration, damage and collagen loss.

Numbing

Topical anaesthetic cream applied 30 minutes before treatment.

Injection

PDRN injected via serial papule technique or microbolus method into the dermis across the target zone.

Recovery

Tiny injection points visible for 24–48 hours. Skin appears refreshed and more hydrated within 1–2 weeks.

Recovery & Aftercare

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Frequently Asked Questions About Polynucleotide (PDRN) Therapy

What is the difference between PDRN and PN therapy?

PDRN (polydeoxyribonucleotide) refers to shorter DNA fragments with a molecular weight below 1,000 kDa. PN (polynucleotide) covers a broader range. Both work through the same PDRN receptor pathway. Products like Rejuran use PN; both are clinically effective and biocompatible.

Is PDRN therapy the same as a skin booster?

No. Skin boosters like Juvederm Volite or Profhilo use hyaluronic acid to add hydration externally. PDRN works at the DNA repair level, stimulating your own cells to produce new collagen and elastin — the effect is biological regeneration, not external hydration alone.

How many sessions does PDRN therapy require?

A course of 3–4 sessions at 2–3 week intervals is standard. Maintenance sessions every 3–6 months are recommended to sustain results.